Abstract
Domain rearrangements in the innate immune network of amphioxus suggests that domain shuffling has shaped the evolution of immune systems.
Highlights
Regulation in protein networks often utilizes specialized domains that 'join' the network through specific protein-protein interactions
The group of proteins involved in apoptosis, members of which incorporate the death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) [1], and the group of Genome Biology 2008, 9:R123 http://genomebiology.com/2008/9/8/R123
Genome Biology 2008, Volume 9, Issue 8, Article R123 Zhang et al R123.2 proteins involved in innate immunity, members of which incorporate the Toll/interleukin-1 receptor (TIR) domains [2,3], represent excellent examples of such networks
Summary
Regulation in protein networks often utilizes specialized domains that 'join' (or 'connect') the network through specific protein-protein interactions. Protein networks are often 'joined' (or 'connected') by specialized protein-protein interaction domains that recognize their targets and connect upstream and downstream elements of the network. Genome Biology 2008, Volume 9, Issue 8, Article R123 Zhang et al R123.2 proteins involved in innate immunity, members of which incorporate the Toll/interleukin-1 receptor (TIR) domains [2,3], represent excellent examples of such networks. We have shown that the evolution of the apoptotic regulatory network consists of a succession of lineage-specific expansions and losses, which, combined with the limited number of 'apoptotic' protein families, has resulted in apparent similarities between networks in different organisms that mask an underlying complex evolutionary history [9]. We focus our analysis on the innate immune system and discuss the potential effects of domain rearrangements on network topology
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