Abstract
The major inhibitory neurotransmitter γ-amino butyric acid (GABA) exerts its inhibitory effect by binding to three different classes of receptors: GABAA-, GABAB- and GABAC receptors. GABAA- and GABAC are both ligand gated chloride ion channels, while GABAB are G-protein coupled receptors. GABAA receptors are important therapeutic targets for anxiety disorders, cognitive disorders, epilepsies, mood disorders, schizophrenia and sleep disorders. Due to the commercial interest, many compound classes, such as benzodiazepines, steroids, and barbiturates, are known to allosterically modify the effect of GABA by binding to distinct sites of the GABAA receptors.
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