Abstract
We identified a genotype G10P[14] rotavirus strain in 5 children and 1 adult with acute gastroenteritis from the Northern Territory, Australia. Full genome sequence analysis identified an artiodactyl-like (bovine, ovine, and camelid) G10-P[14]-I2-R2-C2-M2-A11-N2-T6-E2-H3 genome constellation. This finding suggests artiodactyl-to-human transmission and strengthens the need to continue rotavirus strain surveillance.
Highlights
We identified a genotype G10P[14] rotavirus strain in 5 children and 1 adult with acute gastroenteritis from the Northern Territory, Australia
Phylogenetic analysis of VP1, VP2, NSP2, and NSP3 demonstrated that V585 clustered with genes of rotaviruses identified in the mammalian order Artiodactyla and human strains derived from zoonotic infections (Figure 2, Appendix, panels A, B, F, G, wwwnc.cdc.gov/EID/article/19/8/12-1653-F2.htm)
With the exception of the VP7 gene, the constellation is consistent with G6P[14] and G8P[14] strains identified globally: G6/G8-P[14]-I2-(R2/R5)-C2-M2-(A3/A11)-N2-T6-(E2/ E12)-H3 (6)
Summary
Phylogenetic analysis of the VP7 gene identified 10 lineages (Figure 1, panel A). The 6 G10P[14] strains from NT (lineage IX) were distinct from human G10P[14] rotaviruses RVA/human-tc-GBR/A64/1987/G10P14 II) and RVA/human-tc/THA/Mc35/1987–1989/G10P[14] (lineage V), and they were most closely related to bovine strains identified predominantly in Ireland, China, and Australia (lineage IV). V585 had the highest level of nucleotide
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