Abstract
Purpose: To analyze the quantitative parameters acquired by optical coherence tomography angiography (OCTA) in patients with autoimmune posterior uveitis.Methods: OCTA images of 65 eyes affected with uveitis and 65 normal control (NC) eyes were obtained. The central macular thickness (CMT), retinal thicknesses, foveal avascular zone (FAZ) area, foveal density 300 μm (FD300), and vascular density (VD) were compared among acute uveitic eyes, chronic uveitic eyes, and NC eyes. VDs were evaluated in the choriocapillaris, outer retina, optic disk, whole and parafovea superficial capillary plexus (SCP), and whole and parafovea deep capillary plexus (DCP). Correlation analysis was used to analyze the relationship between LogMAR best-corrected visual acuity (BCVA) and quantitative parameters from OCTA.Results: Compared with NC eyes, the CMT and retinal thicknesses were increased significantly in eyes with uveitis (p < 0.05, respectively). No significant difference was observed in the FAZ area. FD300, VDs in the optic disk, SCP, and DCP both in whole image and parafovea, choriocapillaris were significantly decreased in uveitis eyes (p < 0.05, respectively) compared with NC eyes, only the acute group had decreased VD of the outer retina and choriocapillaris compared with the NC group (p < 0.05). Moreover, quantitative parameters of OCTA showed a significant correlation with LogMAR BCVA in the patients with uveitis. Whole VD DCP was the best predictive factor for BCVA in the patients with uveitis.Conclusion: Quantitative measurement by OCTA is a promising strategy for objective assessment of autoimmune posterior uveitis.
Highlights
Optical coherence tomography angiography is a new noninvasive fundus imaging technique that can be used to acquire information about retinal and choroidal blood flow with high resolution in vivo [1]
foveal density 300 μm (FD300), vascular density (VD) in the optic disk, superficial capillary plexus (SCP), and deep capillary plexus (DCP) both in whole image and parafovea, choriocapillaris were significantly decreased in uveitis eyes (p < 0.05, respectively) compared with normal controls (NCs) eyes, only the acute group had decreased VD of the outer retina and choriocapillaris compared with the NC group (p < 0.05)
Quantitative parameters of optical coherence tomography angiography (OCTA) showed a significant correlation with LogMAR best-corrected visual acuity (BCVA) in the patients with uveitis
Summary
Optical coherence tomography angiography is a new noninvasive fundus imaging technique that can be used to acquire information about retinal and choroidal blood flow with high resolution in vivo [1]. OCTA has unique advantages in the detection of retinal or choroidal vascular changes, the measurement of foveal avascular zone (FAZ), the quantification of vascular density (VD) in the inner retina, outer retinal circulation, or choriocapillaris. OCTA has proved to be an effective diagnostic tool in birdshot chorioretinopathy [7], multifocal choroiditis [8, 9], punctate inner choroidopathy (PIC) [10], acute macular neuroretinopathy [11], multiple evanescent white dot syndrome [12], acute posterior multifocal placoid pigment epitheliopathy (APMPPE) [13], and serpiginous-like choroiditis [14]. Published studies on the quantitative analysis of OCTA in uveitis are very limited, especially in patients with posterior segmentinvolved autoimmune uveitis. There is a lack of investigation about the vascular beds below the retinal pigmented epithelium (RPE) complex, quantitative analysis of the outer retina, or choriocapillaris abnormalities
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
