Abstract
Analogues of 1-0-hexadecyl-2-acyl-sn-glycero-3-phosphorylcholine with different 2-acyl substituents are chemotactic for human neutrophils and mononuclear leukocytes and influence other leukocyte functions. The double bond of the 2-maleyl-analogue results in increased chemotactic potency and a free carboxyl-group endows the 2-maleyl- and 2-succinyl-analogues with the capacity to increase neutrophil adherence, while only the 2-acetyl-analogue exhibits secretagogue activity for lysosomal enzymes. Each of the analogues profoundly alters the responsiveness of neutrophils to other chemotactic stimuli without affecting random migration. The distinct profile of functions of each analogue suggests that studies of this new class of leukotactic mediators may contribute to the elucidation of the mechanisms of leukocyte activation.
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