Abstract
Commonly used organic solvents for spectrophotometric analysis of water insoluble drugs include alcohol, chloroform, benzene, methylene chloride, dimethyl formamide, acetonitrile, toluene, acetone and hexane. The main drawbacks of organic solvents are high value, toxicity and pollution. Hence, it is essential to replace the organic solvents by other eco-friendly alternative sources. Hydrotropic solubilization technique is the best approach to increase the water solubility of poorly water-soluble drugs and overcome the problems related with organic solvents. The present investigation is an attempt to show application of hydrotropic technique using aqueous solutions of N, N-dimethylurea as a hydrotropic agent for extraction of a poorly water soluble drug, diclofenac sodium, from its tablet formulation. The present research work also provides an ecofriendly method to estimate spectrophotometrically the diclofenac sodium drug in tablet formulations without help of an organic solvent. Proposed spectrophotometric method was found to be novel, accurate, economic, ecofriendly and free from toxicity of organic solvent.
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