Abstract
An approach of drug delivery to hypovascular tumor tissues is proposed. For such tumor tissues, it is difficult to deliver anti-tumor agents at enough concentration and duration by either systemic or local administration. If we could manipulate the distribution of locally injected drugs by ultrasound, an efficient drug therapy would be possible. We have found that locally injected perfluorocarbon droplets (PCNDs) induce mechanical effects when exposed to pulsed HIFU at intensity of several kW/cm2 and further that controllable tissue destruction is possible with the effects. In this paper, preliminary results on a new drug delivery system (DDS) by utilizing such effects will be presented.
Highlights
Background/introduction An approach of drug delivery to hypovascular tumor tissues is proposed
We have found that locally injected perfluorocarbon droplets (PCNDs) induce mechanical effects when exposed to pulsed HIFU at intensity of several kW/cm2 and further that controllable tissue destruction is possible with the effects
In vitro experiments: It was found that the pulsed HIFU application induced the drug transportation toward the transducer
Summary
Background/introduction An approach of drug delivery to hypovascular tumor tissues is proposed. If we could manipulate the distribution of locally injected drugs by ultrasound, an efficient drug therapy would be possible. We have found that locally injected perfluorocarbon droplets (PCNDs) induce mechanical effects when exposed to pulsed HIFU at intensity of several kW/cm2 and further that controllable tissue destruction is possible with the effects. PCNDs and sham drug particles (black ink) were incorporated.
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