Novel drug delivery system by chitin derivative

Abstract

AbstractA porous chitin foam was regenerated from chitin dope in calcium chloride dihydrate saturated methanol. The porous chitin foam was shown to have cationic property, because chitin foam tended to adsorb anionic dyes through ionic binding and hydrophobic interaction. A pendant type of polymeric drug was prepared applying peptide spacer composed of phenylalanine at amino end and two step hydrolyses of polymeric drug were shown to release active drug at the final step using lysozyme and chymotrypsin in vitro.