Abstract

AbstractConvenient domino protocol was developed for the synthesis of 2‐arylquinazolin‐4‐amines by the reaction of N‐(2‐cyanophenyl) substituted benzimidoyl isothiocyanates with isopropyl amine. The major advantages of this protocol are short reaction times, mild conditions, simple work up, high yields, and pure products. The efficacy of this protocol owes to the competence of synthesis, pure isolation of imidoyl isothiocyanates, and the unique structure conformation of the corresponding intermediate thiourea derivatives.

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