Abstract
Two new dinuclear Ru(II) arene M2L2 metallocycle complexes [Ru2( η 6- p -cymene)2(m-bitmb)2Cl2](SbF6)2 ( 1 ) and [Ru2( η 6-p-cymene)2(m-bitmb)2Cl2](CF3COO)2 ( 2 ) ( m -bitmb=1,3-bis(imidazol-1-ymethyl)-2,4,6-trimethylbenzene) were synthesized and characterized by single crystal X-ray diffraction, 1H NMR, ESI-MS and elemental analysis. Results revealed that complex 1 and 2 are M2L2 dinuclear Ru–arene complexes with unique “chair-like” conformation. Both of complexes 1 and 2 had certain anti-cancer activity, and complex 2 performed good cytotoxic effect on HeLa cells. The results of circular dichroism and agarose gel electrophoresis experiments indicated that complexes 1 and 2 could change the conformation of CT-DNA and PRB322 DNA. Moreover, compared with 1 , 2 presented much stronger interaction with DNA, which was in accordance with their anti-cancer activities.
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