Abstract
Accurate knowledge of flow rate is critical when quantifying analytes in a chromatographic separation. Using the flow rate, the area of a peak and the response factor of a detector one can calculate the total quantity of the analyte being examined. To date, this quantification has not been possible since no in situ method for flow rate detection within a detector existed. We have developed and tested a novel device and method for measuring the linear flow rate in a micro-gas chromatography (GC) system. Our design utilizes a high-sensitivity micro thermal conductivity detector (μTCD), which is capable of replacing a traditional TCD and requires no calibration for the precise measurement of flow rates. Furthermore, this measurement occurs exactly where the solute elutes from the GC separation column, the point at which knowledge of flow rate is most critical for analyte quantification. To the best of our knowledge, no other method of measuring the flow rate directly at the sensor currently exists.
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