Abstract
Dermal disorders such as psoriasis and eczema are associated with modifications in the chemical and molecular composition of the skin. Clobetasol propionate (CP), a superpotent topical glucocorticoid, is widely used for the therapeutic management of various skin conditions, owing to its strong anti-inflammatory, antipruritic, vasoconstrictive, and antiproliferative activities. Safety studies demonstrated that CP is safer for a shorter period, however, with prolonged application, it shows secondary side effects such as photosensitivity, Cushing-like syndrome, allergic contact dermatitis, osteonecrosis, hypopigmentation, steroid acne, and skin atrophy. Therefore, the US FDA (United States Food and Drug Administration) has restricted the usage of CP to not more than 15 days. Research scientists addressed its several formulations and drug delivery issues, such as low water solubility, less stability, photodegradation, and poor absorption, by incorporating them into novel nanobased delivery platforms. With the utilization of these technologies, these drawbacks of CP have been resolved to a large extent to reestablish this moiety. This article explores the physicochemical properties and mechanism of action of CP. Additionally, an attempt has been made to discover and highlight the possible features of the novel nanosystems, including nanoemulsions, nanosponges, solid lipid nanoparticles, nanostructured lipid carriers, and nanogels, reported for CP. The stability and safety concerns of CP, along with its commercial status, are also discussed.
Highlights
Glucocorticoids are very effective moieties extensively employed in the therapeutic management of inflammatory and pruritic presentations of various dermatological conditions
clobetasol propionate (CP) is usually prescribed for the treatment and management of eczema, psoriasis, contact dermatitis, dry hyperkeratotic dermatoses, atopic dermatitis, discoid lumps erythema, lichen planus, and granulomatous disorders [10,17]
An in vivo imiquimod induced psoriasis mouse model revealed the potential benefits of CP-loaded chitin nanogel in dermal delivery for psoriasis management [7]
Summary
Glucocorticoids are very effective moieties extensively employed in the therapeutic management of inflammatory and pruritic presentations of various dermatological conditions. CP is a pharmaceutically challenging molecule due to poor water solubility and susceptibility to photodegradation Even though it shows potential clinical value, it promotes secondary unfavorable effects because of systemic absorption after topical application. For prevention and management of adverse effects, nowadays, researchers have been continuously paying attention to the development of a variety of drug delivery payloads Such novel cargos are currently in progress to enhance the curative benefits and safety of this potent therapeutic agent. The focus of this review is the assessment of obstacles and the success of these novel carrier systems for facilitating effective CP delivery and its dermal targeting This appraisal represents an effort to furnish an outline of in vitro and ex vivo research performed for CP. This review article will surely provide fresh perspectives for scientists for exploring this molecule
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