Abstract
The diatomic free radical nitric oxide (NO) plays a crucial role in many physiological functions including vasodilation, angiogenesis, and neurotransmission, as well as some immune responses. NO-mediated processes allude to the possibility that chemical systems capable of generating NO may provide useful therapeutic applications. We present here a method to fabricate an NO-releasing bandage. Zeolite A was embedded within porous polylactic acid fibers of a nonwoven mat generated by electrospinning. These composite fibers were then subjected to mild heat treatment, softening the polymer to encapsulate the embedded zeolite and effectively slowing the nitric oxide release.
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