Abstract
Pyrrole and its analogs have garnered immense attention due to their multifaceted biological significance and versatile applications, ranging from medicinal agents to fundamental biological pigments. Despite their prominence, pyrrole synthesis with multiple substituents is complex and calls for innovative approaches to green chemistry. This study delves into synthesizing novel 3,5-dimethyl-1H-pyrroles via multicomponent reactions (MCRs) employing deep eutectic solvents (DES). Due to their eco-friendly nature, these DESs provide a safer substitute for traditional solvents. Specifically, a novel three-component DES (3CDES) was formulated, showcasing promising catalytic activity for multiple cycles with excellent product generation. The synergy between MCR and DES elucidates their combined potential in fostering a sustainable and efficient green synthesis route with the E-factor of 0.1699.
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