Abstract
Cosic discovered that spectral analyses of a protein sequence after each constituent amino acid had been transformed into an appropriate pseudopotential predicted a resonant energy between interacting molecules. Several experimental studies have verified the predicted peak wavelength of photons within the visible or near-visible light band for specific molecules. Here, this concept has been applied to a classic signaling pathway, JAK–STAT, traditionally composed of nine sequential protein interactions. The weighted linear average of the spectral power density (SPD) profiles of each of the eight “precursor” proteins displayed remarkable congruence with the SPD profile of the terminal molecule (CASP-9) in the pathway. These results suggest that classic and complex signaling pathways in cells can also be expressed as combinations of resonance energies.
Highlights
Cosic discovered that spectral analyses of a protein sequence after each constituent amino acid had been transformed into an appropriate pseudopotential predicted a resonant energy between interacting molecules
We present evidence that the JAK (Janus Kinase)– STAT (Signal Transducer and Activator of Transcription) pathway, one of the classic signaling pathways within the cell whose final component affects the nucleus, can be described as a resonance pattern that is composed of the spectral characteristics of the pathway that converge at the nuclear interface as caspase 9 (CASP-9)
The protein interactions can be considered a transfer of resonant energy between interacting molecules through an oscillating physical field that could be expressed within the domain of classic photons
Summary
Cosic discovered that spectral analyses of a protein sequence after each constituent amino acid had been transformed into an appropriate pseudopotential predicted a resonant energy between interacting molecules. There may be an valid energy-based process [2] involving the correlative spatial resonance [3] and resulting spectral power density (SPD) of the specific properties of the units of molecules.
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