Novel Contact Lenses Embedded with Drug-Loaded Zwitterionic Nanogels for Extended Ophthalmic Drug Delivery.

Zhao Wang,Xiaojuan Zhang,Wenli Song,Xinhua Li,Ruilong Sheng,Qing Lin,Lingyun Hao

doi:10.3390/nano11092328

Zhao Wang, Xiaojuan Zhang + Show 5 more

Open Access

https://doi.org/10.3390/nano11092328

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Abstract

Therapeutic ophthalmic contact lenses with prolonged drug release and improved bioavailability have been developed to circumvent tedious eye drop instillation. In this work, zwitterionic nanogels based on poly(sulfobetaine methacrylate) (PSBMA) were easily fabricated by one-step reflux-precipitation polymerization, with the advantages of being surfactant-free and morphology controlled. Then, the ophthalmic drug levofloxacin (LEV) was encapsulated into the nanogels. A set of contact lenses with varied nanogel-loading content was fabricated by the cast molding method, with the drug-loaded nanogels dispersed in pre-monomer solutions composed of 2-hydroxyethyl methacrylate (HEMA) and N-vinyl-2-pyrrolidone (NVP). The structure, surface morphology, water contact angle (WCA), equilibrium water content (EWC), transmittance, and mechanical properties of the contact lenses were subsequently investigated, and in vitro drug release and biocompatibility were further evaluated. As a result, the optimized contact lens with nanogel-loading content of 8 wt% could sustainably deliver LEV for ten days, with critical lens properties within the range of recommended values for commercial contact lenses. Moreover, cell viability assays revealed that the prepared contact lenses were cytocompatible, suggesting their significant potential as an alternative to traditional eye drops or ointment formulations for long-term oculopathy treatment.

Highlights

IntroductionTopical delivery (i.e., eye drops and ointments), is the preferred route of administration and accounts for more than 90% of ophthalmic formulations on the market [2]
With the rapid growth in the aging population and the prevalence of electronic products, the number of people afflicted with ocular diseases is increasing year by year [1].Topical delivery, is the preferred route of administration and accounts for more than 90% of ophthalmic formulations on the market [2]
A special contact lens made of Bri@LDH/Thermogel composite drug delivery system (DDS) developed by Sun et al [26] showed sustained brimonidine release for up to 168 h, and effectively relieved intraocular pressure (IOP)

Summary

Introduction

Topical delivery (i.e., eye drops and ointments), is the preferred route of administration and accounts for more than 90% of ophthalmic formulations on the market [2]. Contact lenses have been widely used by millions of people worldwide for decades for vision correction [5]. They are biocompatible, safe, durable and comfortable, providing a new route for ophthalmic drug delivery [6]. Numerous animal studies demonstrated that ophthalmic medications delivered by therapeutic contact lenses could prolong the time a drug stays on the cornea and increase its bioavailability by at least 50%, compared with eye-drop formulations [1,7].

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