Abstract
Allergic contact dermatitis (ACD) is caused by chemical-reactive T cells. A prerequisite for their activation is the induction of skin inflammation by contact allergens. This requires the activation of signaling pathways of the innate immune system which are also activated in anti-infectious immune responses. The mechanistic basis of the essential innate inflammatory response to chemical allergens and its implications for pathogenesis, therapy, and immunotoxicology will be discussed in this minireview.
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