Abstract
Purpose: Knee osteoarthritis (OA) is a degenerative disease associated with pain, loss of function and possible need for total knee replacement (TKR). TKR is driven by disease severity and many other non-clinical factors; consequently, studying TKR endpoints for OA clinical trials has not been optimal. The recent report from Kim et al. (Kim et al., 2020) proposes the use of composite clinical endpoints based on combinations of severe pain and/or functional impairment utilizing WOMAC (Likert version) or the occurrence of TKR.
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