Abstract
A urea adsorbent with an aldo structure was obtained by the oxidation of a crosslinked β-cyclodextrin polymer. The highest urea adsorption capacity reached 50.6 mg/g in 0.05 M aqueous phosphate buffer at 37°C and pH = 7.4, and decreased to 4.0 mg/g in aqueous human serum albumin. The novel composite adsorbent was prepared by the oxidation of a crosslinked β-cyclodextrin and cellulose dialytic membrane. It was found that the composite adsorbent had a higher urea adsorption selectivity and capacity compared with that of the oxidation of a crosslinked β-cyclodextrin adsorbent when urea is in aqueous human serum albumin. Copyright © 1999 John Wiley & Sons, Ltd.
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