Abstract
Purpose: Plasmonic photo thermal therapy (PPTT) is a therapeutic method in which the photon energy is rapidly transformed into heat via a series of radiative and non-radiative phenomena to ablate cancer. Plasmonic NPs, such as silver NPs (Ag NPs), have considerable properties in optical absorbance. Furthermore, good thermal conductivity and cell penetration ability of carbon nanotubes (CNTs) could improve the efficacy of Ag NPs for PPTT. Decoration of the multi-walled carbon nanotubes (MWCNTs) with silver has been developed to enhance thermal conductivity of the MWCNT particles.Methods: The Ag NPs were decorated on the CNTs and the ability of these particles (CNT/Ag NPs) in reduction of melanoma tumor size after PTT was evaluated experimentally. For comparison, the PTT of silver nanorods (Ag NRs) and CNTs were investigated. The melanoma tumor was induced by injection of B16/F10 cell line to the inbred mice. Different NPs were injected into the tumors and then irradiated via laser diode (λ=670 nm, P=500 mW, and I= 3.5 W/cm2) at scheduled time.Results: Monitoring of tumor sizes showed that integration of CNTs with silver could enhance the optical absorption of CNTs and improve tumor destruction in PPTT technique.Conclusion: The CNT/Ag NPs could act as a potent agent in PPTT method in curing solid tumors.
Highlights
Cancer is a disease defined by invasive and uncontrolled growth of abnormal cells
It was observed that a continuous layer of polyethylene glycol (PEG) with the average thickness of a few nanometers was formed on the carbon nanotubes (CNTs)/as silver NPs (Ag NPs)
This image shows that a continuous layer of PEG with average thickness of 6 nm was formed on Ag nanorods (Ag NRs)
Summary
Cancer is a disease defined by invasive and uncontrolled growth of abnormal cells. Current primary treatments for cancer are surgery, radiation, and chemotherapy. Hyperthermia makes irreversible cell damage by rupturing cell membranes, denaturing proteins, and cell cavitation and degeneration leading to cellular necrosis and apoptosis.[1,7] Thermal tumor therapies, based on hyperthermia phenomenon,[8] has been expanded by different kinds of nanomaterials, including gold NPs,[9,10] silver NPs,[11,12] and carbon nanotubes (CNTs).[13] Metal NPs have ample applications in electronics, photonics,[14,15] chemical sensing, and imaging.[16] Lately, the plasmonic noble metal NPs have attracted a growing deal of interest to themselves They have considerable impacts on the visible and invisible spectra, which could
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
