NOVEL Co(II) Ni(II) AND Cu(II) COMPLEXES OF TRIDENTATE ONS DONOR SCHIFF BASE LIGANDS: SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE, MOLECULAR DOCKING, ANTIOXIDANT AND ANTIMICROBIAL STUDIES

Abstract

A new Schiff base ligand 2-((2-furylmethylene)amino)benzenethiol of the type ONS has been synthesized from 2- aminothiophenol and 2-furfuraldehyde and complexed with Co(II), Ni(II) and Cu(II) metal ions. The synthesized ligand and complexes [Co(II),Ni(II) 8Cu(II)] were characterized using various spectral techniques viz., IR, NMR, EI-MS and thermogravimetric analysis. The geometry of the synthesized complexes was confirmed by electronic spectra, magnetic moment measurements and EPR analysis. DNA cleavage studies were performed using Gel electrophoresis method. The antibacterial activity of all the metal complexes studied against Gram positive bacterial strains Bacillus substilis, Staphylococcus aureus, and also Gram negative bacteria Escherichia coli, Pseudomonas fluorescens and Klebsiella pneumoniae with comparison to Gentamycin. Antifungal activities were carried out against two fungal strains i.e. Aspergillus Niger and Candida albicans. Schiff base and its metal complexes were also screened for in vitro antioxidant activity and was observed that the Co(II) complex shows enhanced activity when compared to ligand and other metal complexes and was further substantiated by molecular docking studies.