Abstract
ObjectivesTo study the technical effectiveness of a novel extracorporeal CO2 removal device in removing CO2 from blood. Study designProspective animal study. AnimalsFive adult female healthy pigs. MethodsHypercapnic pigs were equipped with a low-flow CO2 removal device (PrismaLung®, Hospal®) integrated on a CRRT platform. The rate of CO2 elimination was examined in vivo using a hollow fiber gas exchanger under various conditions (blood flow rates: 200, 300 and 400mL/min; sweep gas flows: 2, 5, 10 and 50 L/min; FsO2: 0.21 and 1). Statistical analysis was performed with Student t-test. ResultsThe extracorporeal device produced CO2 removal rates ranging from 35 to 75mL/min. Efficiency was increased with higher blood and sweep gas flows: reduction of PCO2 of 40.2±13.0mmHg (relative decrease of 46%, P<0.001) and increase in pH of 0.24±0.06 (7.21 before and 7.46 after filter, P<0.001). Animals’ blood gases were significantly modified after 10minutes of treatment: PaCO2 decreased from 81.2 to 70.0mmHg (relative decrease of 14%, P<0.001) and pH increased from 7.17 to 7.22 (P<0.001). No significant changes in arterial blood oxygenation were observed when using pure oxygen (increase of PaO2 from 106 to 107mmHg, P=0.36), allowing the use of ambient air as sweep gas through the membrane. ConclusionsA device based on a Prismaflex® platform was technically effective in removing CO2 from the blood, thus decreasing PaCO2 and acidosis in hypercapnic pigs.
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