Novel chiral stationary phases for optical resolution by ligand-exchange high-performance liquid chromatography

Abstract

Novel chiral stationary phases, (1 R,2 S)- and diastereomeric (1 S,2 S)-2-carboxymethylamino-1,2-diphenylethanol, were prepared from (1 R,2 S)- and (1 S,2 S)-2-amino-1,2-diphenylethanol, respectively, and were bound to silica gel pretreated with 3-glycidoxypropyltrimethoxysilane. The chiral stationary phases were found to be very effective for the optical resolution of amino acids, amino acid derivatives and hydroxy acids by ligand-exchange high-performance liquid chromatography.