Abstract
Fast chiral liquid chromatographic methods are developed for the separation of bicalutamide and thalidomide enantiomers in bulk drug samples in an elution time of about 15 min. The chromatographic separation was carried out on various solvents using an amylose 3,5-dimethylphenylcarbamate immobilized onto silica gel (Chiralpak®-IA). The resolution (Rs) between the enantiomers is found to be greater than 1.5 in the developed method. Chiralpak®-IA column played a key role in achieving chromatographic resolution between the enantiomers and also in enhancing chromatographic efficiency. The columns compatability to non standard chromatographic solvents is checked and found suitable. Keywords: Bicalutamide, Thalidomide, Chiralpak®-IA, Enantiomeric separation, Non-Steroidal Anti-Androgen, Sedative-Hypnotic, Multiple Myeloma, Pharmacokinetic, HPLC, Limit of Quantification, Precision, Robustness
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