Abstract
Precise detection of intracellular Cys will be helpful to accurately assess the physiological functions in the physiological and pathological processes. Herein, a new probe Meoeth-Cy-OBz-oCl capable of Cys sensing with high selectivity over other mercaptoamino-acid molecules including Hcy and GSH was developed. The studies on sensing mechanism supported thiols-induced SNAr substitution-rearrangement cascade reaction which allowed discriminating Cys from Hcy/GSH. And its preferential fluorescence response of Meoeth-Cy-OBz-oCl to intracellular Cys was also achieved by means of fluorescence imaging in HeLa cells. Besides, Meoeth-Cy-OBz-oCl was confirmed possessing mitochondria-targeting ability in living cells. In addition, fluorescence imaging in BALB/c mice revealed that Meoeth-Cy-OBz-oCl could visually monitor the variation of Cys in vivo.
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