Abstract
Multifunctional nanocomposites can combine multiple functions into a single nanosystem and thus have attracted extensive interest in various fields. The combination of magnetic and upconversion luminescent nanoparticles into one single nanoplatform, which have a good application in biomedical fields such as bio-magnetic separation, magnetic resonance imaging (MRI), and optical imaging, is highly desirable. Here we reported multifunctional nanocomposites by using hollow carbon sphere to integrate magnetic Fe3O4 and upconversion nanoparticles (UCNPs) into one nanosystem. The as-prepared UCNPs/Fe3O4@h-C have near-infrared (NIR) luminescence under 980 nm excitation and superparamagnetism. In addition, since the carbon layer can absorb NIR light and transfer it into heat with high efficiency, the nanocomposites can realize photo thermal (PT), upconversion luminescence (UCL) and MRI tri-mode imaging. The UCNPs/Fe3O4@h-C might be further utilized as a potential theranostic agent, including its in-depth monitoring through luminescent imaging and MRI diagnosis, as well as its direct use in tumors as a photothermal therapy (PTT) agent.
Highlights
In recent years, multifunctional nanocomposite materials have attracted extensive interest because they can integrate multiple functionalities into one single nanosystem and endow them with great potential application in various areas (Gao et al, 2009; Liu Z. et al, 2011; Cheng et al, 2013; Jia et al, 2019; Sun et al, 2019; Liao et al, 2020)
The temperature of the mixture was raised to 500◦C and kept for 2 h under the atmosphere of Ar (95%) and H2 (5%) to generate the carbon shell from dihydroxybenzoic acid (DA) reduction (Sun et al, 2013)
The carbon-based multifunctional nanocomposites were obtained by means of the hollow carbon sphere to make Fe3O4 and upconversion nanoparticles (UCNPs) locate in the hollow cavity at the same time
Summary
Multifunctional nanocomposite materials have attracted extensive interest because they can integrate multiple functionalities into one single nanosystem and endow them with great potential application in various areas (Gao et al, 2009; Liu Z. et al, 2011; Cheng et al, 2013; Jia et al, 2019; Sun et al, 2019; Liao et al, 2020). Rare-earth doped upconversion luminescent nanomaterials (UCNPs) can emit high-energy photons of different wavelengths in visible or near-infrared (NIR) region by absorbing two or more low-energy photons in NIR region, this makes UCNPs have the prominent advantages over traditional phosphors in low autofluorescence background, shape emission bandwidths, good photochemical stability, and large tissue penetration depth (Xu et al, 2018; Zhu et al, 2018; Zhang et al, 2019) These unique properties proposed UCNPs as a new generation of optical materials in luminescent detections with high sensitivity, high resolution bioimaging, photodynamic therapies (PDT), and so on Magnetic nanoparticles are another kind of attractive materials for biomedicine because
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