Abstract
The degradation of aromatic compounds by bacteria is dependent upon specific catabolic operons. The uniquecarlocus isolated fromSphingomonasCB3 encodes the first four enzymes involved in the catabolism of the azaarene carbazole. These include a class II three-component dioxygenase enzyme system, a dihydrodiol dehydrogenase, an extradiol (meta-cleavage) dioxygenase, and a hydrolase. Homology of deduced amino acid sequences is closer to corresponding biphenyl catabolic genes than to previously characterised carbazole degradation genes. Gene arrangement is also identical to that found in somebphloci. Thecargenes are transcribed when carbazole is utilised as a sole carbon source, and although biphenyl does not serve as a growth substrate forSphingomonasCB3 it is able to act as a non-metabolisable inducer of thecarlocus. Ecologically thecargenes were detected in polycyclic aromatic hydrocarbon (PAH) contaminated soil associated with a former town gas site.
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