Novel biomolecules in targeted cancer therapy: a new approach towards precision medicine.

Abstract

Cancer is a major threat to human life around the globe, and the discovery of novel biomolecules continue to be an urgenttherapeutic need that is still unmet. Precision medicine relies on targetedtherapeutic strategies. Researchers are better equipped to develop therapies that targetproteins as they understand more about the genetic alterations and molecules that cause progression ofcancer. There has been a recent diversification of the sorts of targets exploited in treatment. Therapeutic antibody and biotechnology advancements enabled curative treatments to reach previously inaccessible sites. New treatment strategies have been initiated for several undruggable targets. The application of tailored therapy has been proven to have efficient results in controlling cancer progression. Novel biomolecules like SMDCs, ADCs, mABs, and PROTACS has gained vast attention in the recent years. Several studies have shown that using these novel technology helps in reducing the drug dosage as well as to overcome drug resistance in different cancer types. Therefore, it is crucial to fully untangle the mechanism and collect evidence to understand the significance of these novel drug targets and strategies. This review article will be discussing the importance and role of these novel biomolecules in targeted cancer therapies.