Abstract
Diastolic heart failure (DHF) is increasing in prevalence and incidence, but there are no specific treatments or diagnostic biomarkers known. Recently, we reported that that impaired relaxation is associated with nitric oxide synthase (NOS) uncoupling that results in oxidative modificat ion of card iac myosin binding protein C (MyBP-C), induces slowed myofilament cross-bridge kinetics, and leads to diastolic dysfunction. NOS uncoupling is enhanced by asymmetric dimethylarg inine (ADMA). Plasma ADMA, L-arginine, and symmetric dimethyl arg inine (SDMA) levels were determined from human plasma samples from patients with DHF or systolic HF (SHF) and from a healthy control group. Plasma ADMA level were elevated in both DHF patients (0.77 ± 0.04 μM, P
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