Abstract
A novel amphiphilic biodegradable poly(ethylene glycol)–poly(2-methyl-2-carboxyl-propylene carbonate) (MPEG–PMBC) block copolymer was successfully synthesized by ring-opening polymerization (ROP) of 2-methyl-2-carboxyl-propylene carbonate (MBC) with MPEG as a macroinitiator. 13C NMR and GPC confirmed its structure. It could self-assemble into micelles in aqueous solution with the critical micelle concentration (cmc) as low as ∼10 −3 g/l. The cmc decreased with increasing PMBC content. DLS analyses of the MPEG–PMBC micelles revealed their size of less than 100 nm and narrow size distribution. The micelle size depends much on the copolymer composition and micelle preparation conditions. The morphology of micelle observed by ESEM is spherical. The obtained polymeric micelles are expected to be used as biomedical materials such as drug delivery vehicles.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
