Abstract
Novel glycosyl donors with a triisopropylsilyl (TIPS) nonparticipating group at O-2 were introduced for use in 1,2-cis-fucosylation. Coupling of 2-O-TIPS-substituted thiofucosyl donors with N-trifluoroacetyl-β- d -glucosamine mono- and disaccharide derivatives was found to lead exclusively to α-linked oligosaccharides. No remote participation in 2-O-TIPS thiofucosyl donors seems to be required to favor α-selective fucosylation.
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