Abstract
Genome sequences of chicken (low pathogenic avian influenza [LPAI] and highly pathogenic avian influenza [HPAI]) and human isolates from a 2004 outbreak of H7N3 avian influenza in Canada showed a novel insertion in the HA0 cleavage site of the human and HPAI isolate. This insertion likely occurred by recombination between the hemagglutination and matrix genes in the LPAI virus.
Highlights
Genome sequences of chicken (low pathogenic avian influenza [LPAI] and highly pathogenic avian influenza [Highly pathogenic avian influenza (HPAI)]) and human isolates from a 2004 outbreak of H7N3 avian influenza in Canada showed a novel insertion in the HA0 cleavage site of the human and HPAI isolate
Genome sequences of chicken and human isolates from a 2004 outbreak of H7N3 avian influenza in Canada showed a novel insertion in the HA0 cleavage site of the human and Highly pathogenic avian influenza (HPAI) isolate
All HPAI viruses encode a HA0 protein having a motif of multiple basic amino acids (R and K) flanking the cleavage site
Summary
Genome sequences of chicken (low pathogenic avian influenza [LPAI] and highly pathogenic avian influenza [HPAI]) and human isolates from a 2004 outbreak of H7N3 avian influenza in Canada showed a novel insertion in the HA0 cleavage site of the human and HPAI isolate. All HPAI viruses encode a HA0 protein having a motif of multiple basic amino acids (R and K) flanking the cleavage site. An increase in basic residues near the cleavage site, either as a result of nucleotide insertion or substitution, allows the HA0 precursor to be cleaved by ubiquitous host proteases [5].
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