Novel association between MAVS gene variations and dengue fever

Abstract

AimThis study aimed to determine the association between MAVS gene variants (SNPs rs17857295, rs45437096, and rs7262903) and dengue fever. Methods and materialA case–control study was carried out by recruiting 137 dengue patients and an equal number of age- and gender-matched healthy individuals. The polymerase chain reaction-restriction fragment length polymorphism method was used to determine the genotype of the MAVS gene variants. ResultsThe minor allele frequency of SNP rs17857295 was 2.3 times higher in the patient group (47.4% vs. 20.4%; p ≤0.001; odds ratio 3.5). Likewise, the minor allele frequency of SNP rs45437096 was 1.3 times higher in the patient group (29.9% vs. 23%; p = 0.04; odds ratio 1.4). However, the minor allele frequency of SNP rs7262903 was not significantly different between the patient and control groups (26.6% vs. 21.5%; p = 0.09). ConclusionsThe MAVS gene SNPs rs17857295 and rs45437096 but not rs7262903 are risk factors for contracting dengue fever.