Abstract
ONOCLONAL antibodies (MoAbs) are now routinely used in most medical labo ratories. This is especially true in transfusion med icine where the use of MoAbs has permitted the gradual replacement of many of the human and animal antisera used in the preparation of blood bank reagents· as well as increasing the efficiency of the preparation and testing of blood-derived products, eg, purification of factor VIII,2 virus testing. 3 The impact of MoAbs could be even greater in transfusion medicine because these mol ecules are expected to be essential components of new processes (eg, blood cell separation) and ther apeutic preparations (eg, human MoAbs) that are presently considered for use in the diagnosis and treatment of blood-related disorders. 4 For many of these applications, the transition from conceptualization to active development work has been made possible by significant recent advances in MoAb technology. It is the objective of this review to summarize some of the progress that has been made recently in the development of more efficient laboratory methods for preparing MoAbs and to illustrate the potential impact and the limitations of the use of these techniques in transfusion medicine and in other fields.
Published Version
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