Novel approaches, including systems biology, to HIV vaccine research and development: Report from a Global HIV Vaccine Enterprise Working Group

Rino Rappuoli,Alan Aderem,The ,Bali Pulendran

doi:10.1038/npre.2010.4798.1

Abstract

AbstractThe Global HIV Vaccine Enterprise convened a two-day workshop on August 10-11 2009, at the Fred Hutchison Cancer Research Center offices in Seattle, WA, to discuss the application of novel approaches,including systems biology, to HIV vaccine research and development. The goals of this Working Group were to identify key scientific issues and opportunities that have emerged since the Enterprise Scientific Strategic Plan1 was published in 2005, and to make recommendations to Enterprise stakeholders.

Highlights

The Global HIV Vaccine Enterprise convened a two-day workshop on August 10-11 2009, at the Fred Hutchison Cancer Research Center offices in Seattle, WA, to discuss the application of novel approaches, including systems biology, to HIV vaccine research and development
We will argue here that the new tools of systems biology, when combined with current approaches, will be transformative in understanding the molecular networks underlying the immune response to HIV infection and will enable strategies to re-engineer these networks to generate protective immunity[3,4]
It is important to recognize the critical interplay between technology development and biology; when biological questions cannot be answered with current technologies, new ones need to be developed which, in turn, open new areas of biological inquiry

Summary

Introduction

The Global HIV Vaccine Enterprise convened a two-day workshop on August 10-11 2009, at the Fred Hutchison Cancer Research Center offices in Seattle, WA, to discuss the application of novel approaches, including systems biology, to HIV vaccine research and development. In the discussions of this Working Group, four priority areas were identified that are critical to harness and integrate novel approaches and technological advances into HIV vaccine research and development (Table 1).

Results

Conclusion