Abstract
Background Chronic allergic rhinitis is associated with inflammation of the nasal mucosa, changes in nasal epithelial integrity and subsequent clinical symptoms. Sulfurous (natural mineral) thermal waters (STWs) have been used as complementary therapeutic approach to chronic rhinitis / rhinosinusitis, with studies demonstrating clinical efficacy, namely in terms of improvement in mucociliary clearance time, nasal resistance and nasal flow. However, very few data exist regarding the effects of STW-based treatment on nasal epithelial integrity parameters. We have hypothesized that STWs treatment will modulate an amelioration of general integrity of allergic rhinitis nasal mucosa.
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