Abstract
'Mixed-solvency ' concept is the phenomenon to increase the solubility of poorly water-soluble drugs in the aqueous solution containing blends of hydrotropic agents, co-solvents and water soluble solutes which may give synergistic enhancement effect on solubility of such drugs. In the present study mixed –solvency concept has been applied for the enhancement of aqueous solubility of a poorly water-soluble drug diclofenec sodium(selected as a model drug) by making blends of randomly selected water-soluble substances from among the hydrotropes (urea, sodium citrate) ; water soluble solutes(PEG4000, PEG6000); and co-solvents(PEG300,PEG400). The aqueous solubility of diclofenac sodium was observed at room temperature in the randomly selected blends of different combinations keeping total concentration 30%w/v constant. Quantitative analysis of bulk drug diclofenec sodium was done by u.v. spectrophotometric estimation at λmax at 276 nm in concentration range of 15-90 µg/ml . The results suggests significant enhancement in the solubility of the poorly water soluble drug sample containing different combinations of such substances (blends).
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