Novel antioxidant agents deriving from molecular combination of Vitamin C and NO-donor moieties

Abstract

In this paper, we describe a new class of products in which NO-donor moieties are linked to either the 3- OH ( 4a– f) or 2- OH group ( 7a– c) of ascorbic acid (ASA). Log Ps and p K as of these products were experimentally evaluated. All the compounds were tested for their antioxidant activity on lipidic peroxidation induced by Fe 3+-ADP/NADPH in lipids of microsomal membranes of rat hepatocytes. Only 3- O series displays antioxidant activity and it seems to be principally dependent on the lipophilicity. Both series trigger in vitro NO-dependent vasodilator properties.