Abstract
Aim: A series of new hybrid molecules with two iodine atoms on thesides were synthesized. Methods: A one-pot, two-component methodwith trifluoroacetic acid as aneffective catalystto obtain dihydro-pyrrol-2-one compoundswas developed. Short reaction times, acheap catalyst, high yields and clean work-up are benefits of this method. Results: The chemical structures of thenewly synthesized compounds were verified through spectroscopic techniques. Their antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans was tested in vitro. Conclusion: NC- and OH- radicals confer broad-spectrum antimicrobial activity, including againstGram-positive and Gram-negative bacteria and yeasts. Compounds 3g >7 and>9 were most active on the two bacterial species, while 3l >9 and >3i were most active against the fungal strain.
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