Abstract
Five new dimer compounds, namely Taiwaniacryptodimers A–E (1–5), were isolated from the methanol extract of the roots of Taiwania cryptomerioides. Their structures were established by mean of spectroscopic analysis and comparison of NMR data with those of known analogues. Their antifungal activities were also evaluated. Our results indicated that metabolites 1, 2, 4, and 5 displayed moderate antifungal activities against Aspergillus niger, Penicillium italicum, Candida albicans, and Saccharomyces cerevisiae.
Highlights
Taiwan cedar (Taiwania cryptomerioides Hayata), known as Asia cedar, is an essential economic tree species native to Taiwan
The EI-MS fragmental ions of 1 at m/z 350 [C20H14O6]+ and 316 [C20H28O3]+, as well as forty carbon signals found in the 13C NMR spectrum hinted that 1 was a dimeric diterpenoid (Figure 1)
Our results indicated that Metabolites 1, 2, 4, and 5 present moderate antifungal activities compared with ketoconazole, for which Compound 3 was weak
Summary
Taiwan cedar (Taiwania cryptomerioides Hayata), known as Asia cedar, is an essential economic tree species native to Taiwan. It belongs to the same Mesozoic and Cenozoic Tertiary relics with Ginkgo biloba, Sequoiadendron giganteum, and Metasequoia glyptostroboides. It is a rare and precious tree species [1]. S. Konisi was first discovered in Nantou County, Taiwan. Konisi was first discovered in Nantou County, Taiwan It was named by the botanist Prof. Decay resistance, and ant resistance are similar to those of cypress. The leaves have the effects of mashing juice and involving poison and are used for anti-inflammatory, diuretic, and gonorrhea treatment
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