Abstract
Glyoxalase I mimetic activity has been associated with the imidazole function. Histidine, histidine methyl ester and carnosine had glyoxalase I mimetic activity under physiological conditions. Carnosine scavenged methylglyoxal to form β-alanyl-N-dl-lactoyl-l-histidine (lactoylcarnosine). This scavenging of α-oxoaldehydes by carnosine, and hydrolysis of the adduct formed to the corresponding aldonic acid catalysed by acyl-histidine hydrolase, represented a glyoxalase system mimetic activity. Glyoxalase mimetics are novel anti-glycation agents that may have therapeutic applications. Their specific activity, however, needs to be improved to have significant pharmacological effect.
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