Abstract
The aim of this study was to investigate anti-aging molecules from Onosma bracteatum Wall, a traditional medicinal plant used in the Unani and Ayurvedic systems of medicine. During bioassay-guided isolation, two known benzoquinones, allomicrophyllone (1) and ehretiquinone (2) along with three novel benzoquinones designated as ehretiquinones B–D (3−5) were isolated from O. bracteatum. Their structures were characterized by spectroscopic analysis through 1D and 2D NMR, by MS spectroscopic analysis and comparing with those reported in the literatures. The anti-aging potential of the isolated benzoquinones was evaluated through a yeast lifespan assay, and the results indicated that 1, 2, 4 and 5 significantly extended the replicative lifespan of K6001 yeast, indicating that these benzoquinones obtained from O. brateatum have the ability to be employed as a potential therapeutic agent against age-related diseases.
Highlights
Aging is a natural process marked by progressive deterioration in physiological functions and increases in mortality and is often accompanied by various human pathologies, such as cardiovascular diseases, diabetes, stroke, cancer and neurodegenerative diseases (Parkinson’s and Alzheimer’s disease) [1]
Of known benzoquinones were under identified guidance of a bioassay system and was purified by to yield two known and as allomicrophyllone (1, 0.0043% of dry weight) [17,18] and ehretiquinone (2, 0.0013%) [19], while three novelof
This study reports the isolation, structure elucidation, biological activity and brief of quality of life of aged people and reduce the prevalence of age-related diseases, are study of great anti-aging benzoquinone derivatives from O. structure bracteatum
Summary
Aging is a natural process marked by progressive deterioration in physiological functions and increases in mortality and is often accompanied by various human pathologies, such as cardiovascular diseases, diabetes, stroke, cancer and neurodegenerative diseases (Parkinson’s and Alzheimer’s disease) [1]. Advances in public health practices, education and medicine have improved life expectancy but have increased the aged population. Strategies for discovering anti-aging molecules are of great importance [3]. We reported many natural compounds with anti-aging properties by using K6001 yeast replicative life span bioassay [4,5,6]. This assay is frequently used because yeast is inexpensive and has good reproducibility compared with other aging model organisms, such as vinegar flies, mice and nematodes [7,8,9,10]. In 2004, Jarolim et al, described a novel bioassay system with the K6001 yeast strain to improve the lifespan assay [11]
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