Abstract
Synthesis of novel angiotensin converting enzyme inhibitors has been accomplished using the α-hydroxy ketomethylene dipeptide isostere as a key constituent. (2 R, 5 S)-2-hydroxy-5-benzamido-4-oxo-6-phenyl hexanoyl ( S)-(−)-indoline-2-carboxylic acid ( 7) showed potent inhibitory activity against angiotensin converting enzyme, IC 50 = 0.09 μM.
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