Novel and Efficient One-Pot Synthesis of (Aminophenyl)carbamic Acid Esters

Abstract

A novel and efficient protocol is developed for the synthesis of various (aminophenyl)carbamic acid esters from the reduction and condensation of nitrophenyl isocyanate derivatives. The reaction takes place in various hydroxy derivatives such as alcohols or phenols under a hydrogen atmosphere using Raney nickel as catalyst. Products are obtained by a convenient one–pot synthesis with excellent yields and short reaction times.