Abstract
In this study, the protocol of a single-step l-cysteine functionalized silver nanoparticle synthesis was described. Particle size distribution was determined. The crystallinity and chemical properties were investigated using XRD, HR-TEM, and XPS methods. Acute toxicity and irritant properties of obtained nanoparticles were studied using mice and rats as an animal model. The results showed that thanks to the applied protocol, it was possible to synthesize silver nanoparticles with narrow particle size distribution. Moreover, the concentration of final product was extremely high in comparison to other known methods. These nanoparticles showed neither irritant properties nor acute toxicity.
Highlights
Throughout the last decades, the nanotechnology has been considered as a powerful field, which finds out the application in many areas of science
Only a few synthesis routes are recommended for medical application as there are problems with the biocompatibility of reagents, or media, etc
X-ray photoelectron spectroscopy (XPS) of AgNPs confirmed the presence of silver nanoparticles with cysteine conjugated to the surfaces of the nanoparticles
Summary
Throughout the last decades, the nanotechnology has been considered as a powerful field, which finds out the application in many areas of science. Particular noble metals, such as gold, platinum, palladium, and silver nanoparticles are considered, due to their unique chemical and physical properties. These particles have low toxicity, high compatibility to biological systems, and can be functionalized, which increase the range of their potential application. For these reasons, gold nanoparticles are used, e.g., in cancer therapy mainly as drug carriers (Cobley et al 2011), delivery vehicles (Galdiero et al 2011), or markers for imaging (Huang et al 2006) etc. The special attention was focused on the functionalization of silver nanoparticles for cosmetic application
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