Abstract
The Objective of this work based on for development of a novel method and validation of method used for determination of amount in manner of assay present into Cefoxitin in bulk and Tablet Dosage form. The aspire and intention of the present study is to expand moreover authenticate a novel as well as rapid reverse phase chromatography separation technique for the estimating Cefoxitin in bulk and dosage form to justify the presence of drug in the developed dosage forms and give satisfaction towards presence of medicine and its assay estimation. As the drug Cefoxitin compendial monograph is not available in Indian Pharmacopoeia and British Pharmacopoeia, but a compendial monograph is available in United Sate Pharmacopoeia i.e. USP- 40 for injection dosage form only. The developed method is new, simple, economic, rapid, eco friendly, accurate, and precise HPLC method for qualitative and quantitative estimation of Cefoxitin in bulk and dosage form like tablet, capsule, injection also.
Highlights
Cefoxitin is a semi synthetic cephamycin antibiotics basically used to treat various bacterial infections
The Objective of this work based on for development of a novel method and validation of method used for determination of amount in manner of assay present into Cefoxitin in bulk and Tablet Dosage form
The aspire and intention of the present study is to expand authenticate a novel as well as rapid reverse phase chromatography separation technique for the estimating Cefoxitin in bulk and dosage form to justify the presence of drug in the developed dosage forms and give satisfaction towards presence of medicine and its assay estimation
Summary
Cefoxitin is a semi synthetic cephamycin antibiotics basically used to treat various bacterial infections. It is highly resistant to a broad spectrum of βlactamase and show efficacy towards wide range of both aerobic & anaerobic gram-positive and gramnegative microorganisms [2, 12]. Molecular formula of Cefoxitin is C16H17N3O7S2 and chemically. Molecular weight of Cefoxitin is 427.454 g/mol. Cefoxitin is sparingly soluble in water and insoluble in crude with PKa value 3.59 [2, 5]
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