Abstract
The aim of our protocol is to develop new simple, economic and efficient scavengers for primary amines, due to their substantial adverse impacts on environment and human health. In this endeavor, we have designed, successfully synthesized and structurally characterized new salicylaldehyde-tri-nbutylammonium ionic liquids which were investigated as scavengers for diverse aromatic and heterocyclic primary amines in the synthesis of new pharmacologically relevant candidates, imines scavenging product, via Schiff-base-scavenging reaction. The new scavengers exhibited good capture efficiency and can be easily regenerated and reused. The advantages of our scavengers over polymer-supported scavengers are the simplicity, shorter reaction time and real-time monitoring of a model reaction. The biocidal and antitumor activities of the scavenging products revealed a moderate to excellent broad-spectrum antibacterial efficacy, low activity or inactivity as fungicides and different levels of cytotoxicity (weak to excellent) against human breast carcinoma (MCF-7) cells.
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