Abstract
The aim of this study is to identify the AKT1 gene mutation driven pathogenicity in gastric cancer for Mizo population. 50 diffuse-type gastric tumors were analyzed for AKT1 exon 2 and 14 mutations. Cell-cycle aberration was analyzed in the AKT1-mutated samples and the stability of the protein as well as exonic splicing enhancer motifs were examined. The novel mutations, 15553T>A and 25376C>G might affect the exonic splicing enhancers and silencers. Significant decline was observed in the S-phase population in the tumor cells with 15553T>A and 15579G>C mutations suggesting the arrest of G1 phase. The present study is a novel finding of the possible role of AKT1 mutations which might help to identify gastric cancer patients.
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