Novel advancements in three-dimensional neural tissue engineering and regenerative medicine.

Abstract

Neurological diseases and injuries present some of the greatest challenges in modern medicine, often causing irreversible and lifelong burdens in the people whom they afflict. These diagnoses have devastating consequences on millions of people each year, and yet there are currently no therapies or interventions that can repair the structure of neural circuits and restore neural tissue function in the brain and spinal cord. Despite the challenges of overcoming these limitations, there are many new approaches under development that hold much promise. Neural tissue engineering aims to restore and influence the function of damaged or diseased neural tissue generally through the use of stem cells and biomaterials. In this paper, several new 3D tissue constructs and designs are described for functional reconstruction of neural architecture. With the use of induced pluripotent stem cells or induced neuronal cells, these 3D constructs could then be studied as regional models of the central nervous system or could one day be implemented as autologous grafts into damaged sites of the nervous system in order to restore neural function, particularly for damaged sites of spinal cord, areas of stroke infarction, tumor resection sites, peripheral nerve injuries, or areas of neurodegeneration.