Novel Adaptation of the Long Suppression Protocol for Fertility Preservation in a Woman With Stage I Receptor-Positive Breast Cancer (BrCa) and Age Factor

Abstract

Background: Advances in diagnosis and therapy allow women with early BrCa to pursue fertility preservation. Most treatment options involve a modified short stimulation protocol with cryopreservation and offer them just a variable chance of future fertility. Only IVF with a gestational surrogate (IVF-GS) can result in an immediate pregnancy, although it requires more time for preparation and follow-up. Delay in treatment may increase BrCa recurrence risk through at least two mechanisms: 1) supraphysiologic estradiol (E2) levels during IVF; 2) prolonged exposure to physiologic E2 levels.